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. 2023 Nov 15;299(12):105462. doi: 10.1016/j.jbc.2023.105462

Figure 7.

Figure 7

The activation of Traf6 by c-Src is positively correlated with Tau pathology in AD brain.A, Western blotting of Traf6, pY473-Traf6, AEP, Tau368, AT8, Tau5, and actin in the brain of control and AD patients. B, quantification of the ratio of pY473-Traf6, mAEP, Tau368 to actin, and AT8 to Tau5 in (A). C, the linear correlation between pY473-Traf6 and mAEP, pY473-Traf6 and Tau368, pY473-Traf6 and AT8, and mAEP and Tau368 was analyzed. Con, n = 5; AD, n = 5. Data are presented as the mean ± SD. ∗p < 0.05. AD, Alzheimer’s disease; AEP, asparaginyl endopeptidase; Traf6, tumor necrosis factor receptor–associated factor 6.