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. 2023 Nov 27;14:1292568. doi: 10.3389/fimmu.2023.1292568

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Copyright © 2023 Rosati, Terpos, Homan, Bergamaschi, Karaliota, Ntanasis-Stathopoulos, Devasundaram, Bear, Burns, Bagratuni, Trougakos, Dimopoulos, Pavlakis and Felber

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequential analysis of biomarkers with longer-lasting changes. (A) The heatmap shows log₂ fold changes comparing all sequential measurements to the day 1 measurements before the 1^st vaccination. d22 samples were collected before 2^nd vaccination, d36, d50, and M9 before the 3^rd vaccination and M10, one month after the 3^rd vaccination. Grey cells denote missing values for five analytes not measured for 22 participants. (B, C) Mean log₂ fold changes for each analyte and for (B) data obtained d22, d36, d50, M9 and M10 from (B, C) and data obtained 24hrs after the 1^st, 2^nd, and the 3^rd vaccination (d2, d23, m9+d1).