TABLE 1.

Summary of the self-determined intranasal DMT dose escalation for study day 3 (top) and 4 (bottom). At the 1st (0-min), 2nd (15-min), and 3rd (30-min) timepoints, the DMT doses were pre-determined by the experimenter (shaded area). At the 4^th (45-min), 5^th (60-min), 6^th (75-min), 7^th (90-min), 8^th (105-min) and 9^th (120-min) timepoints, volunteers were allowed to self-determine the intranasal dose increment based on their general wellbeing. On day 3, either a dose of 0 or 5 mg, and on day 4, either a dose of 0, 5, or 10 mg were allowed. Numbers in the table indicate the number of volunteers that chose the corresponding dose.

Self-determined repeated intermittent dosing regimen
	Dose increment
Day 3	1st	2nd	3rd	4th	5th	6th	7th	8th	9th
0 mg	-	-	-	1	1	1	1	0	2
5 mg	-	10	10	9	9	9	9	10	8
10 mg	10	-	-	0	0	0	0	0	0
Day 4	1st	2nd	3rd	4th	5th	6th	7th	8th	9th
0 mg	-	-	-	0	0	1	1	1	2
5 mg	-	-	-	1	0	0	1	0	0
10 mg	10	10	10	9	10	9	8	9	8