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. 2023 Nov 27;10:1280177. doi: 10.3389/fvets.2023.1280177

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Copyright © 2023 Chen, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The virion structure of PCV3 and its clinical diseases or signs (A) PCV3 has a single-stranded, circular DNA genome, and the capsid consists of 12 pentagonal, trumpet-shaped pentamers. (B) The PCV3 genome is about 2000-nt in length and contains three major ORFs: ORF1, ORF2, and ORF3 (45). (C) A variety of clinical and pathological symptoms are associated with PCV3 infection: ① skin: multifocal papules, macules, and/or superficial dermatitis; ② kidney: lymphoplasmacytic interstitial nephritis and vasculitis; ③ reproductive disorders: abortion, stillbirth, and mummified fetuses; ④ lung: coughing, sneezing, and respiratory distress associated with lymphoplasmacytic interstitial pneumonia; ⑤ digestive disorders.