Figure 5.

Myelin-reactive antibodies such as those against MOG trigger oligodendrocyte stress. This subsequently results in the release of exosomes containing the stress protein αB-crystallin. Antibodies that bind to the oligodendroglial transmembrane protein MOG trigger membrane perturbations and intracellular changes including stress. To counteract apoptosis, oligodendrocytes accumulate intracellular αB-crystallin which is subsequently also secreted as exosome cargo (Figure created with Biorender).