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. 2023 Nov 19;26(12):108487. doi: 10.1016/j.isci.2023.108487

Figure 2.

Figure 2

MYB expression is significantly higher in tumor tissues from Black patients than White patients

(A) Due to a weak MYB staining in a fewer number of BPH cells, no significant differences were observed between White (n = 16) and Black (n = 19) patients. (B) Likewise, no significant difference in MYB positivity and H-scores were detected in the HGPIN lesions from White (n = 21) and Black (n = 17) patients.

(C) MYB expression was significantly higher in the tumor tissues of Black patients (n = 55) than White patients (n = 50) with a greater percentage of cells exhibiting strongly positive staining in Black patients’ samples.

(D and E) In a grade-wise comparison, an elevated MYB expression was observed in both low/moderate (≤7) and advanced grade samples of Black patients (≥8). The data are presented as a boxplot depicting median (horizontal line) value in each group. Top and bottom edges of the box represent 75th (third quartile) and 25th (first quartile) percentiles, respectively, and whiskers point highest and lowest H scores. The differences between groups were calculated by Mann Whitney U statistical test a p value of <0.05 was considered significant. GS: Gleason score.