Fig. 3.

Relationship between histological steatosis grades and PDFF.

(A) Distribution of histological steatosis fraction (purple boxes) and PDFF (green boxes) with respect to histological steatosis grades S0–S3. Horizontal lines within the boxes denote medians and whiskers denote minimum and maximum values. The Mann-Whitney U test was used. ∗∗∗p ≤0.001. (B) Proportion of individuals with steatosis grade mismatch between histology and PDFF, when PDFF is interpreted with the same grading thresholds that are conventionally used for histology (S0: <5%; S1: 5–33%; S2: 34–66%; S3: >66%). (C) Receiver operating characteristic (ROC) curves for PDFF to classify the subjects into dichotomised histological steatosis grades. Areas under the ROC curves (AUROC) are shown. PDFF, proton density fat fraction.