Table 2.

Thresholds and 10-fold cross-validated diagnostic performance parameters for PDFF to predict dichotomised histological steatosis grades at 90% specificity in the pooled cohort.

Steatosis grade classification	Threshold	Se, % (95% CI)	Sp, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)
S0 vs. S1–S3	≥5.75	79.5 (77.2–81.8)	90.1 (85.7–96.1)	96.6 (94.8–98.4)	57.1 (52.9–61.2)
S0–S1 vs. S2–S3	≥15.50	78.8 (73.6–83.9)	90.1 (87.2–93.1)	81.7 (77.0–86.4)	88.6 (85.7–91.5)
S0–S2 vs. S3	≥21.35	69.0 (59.9–78.1)	90.0 (88.6–91.5)	56.7 (52.8–60.5)	94.0 (92.5–95.6)

NPV, negative predictive value; PDFF, proton density fat fraction; PPV, positive predictive value; Se, sensitivity; Sp, specificity.