Table 2:
EORTC QLQ-C30 quality of life scale scores at study enrollment for White and Black participants (N = 879)
| Score for White participants Mean (95% CI), N = 704 |
Difference for Black participants Mean (95% CI), N = 175a |
Standard deviation of participant random effect | Standard deviation of site random effect | ||
|---|---|---|---|---|---|
| UNADJUSTED | ADJUSTED | ||||
| Global Quality of Life (QL) 1 | 70.9 (68.8, 73.0) | −0.6 (−4.0, 2.9) | −0.7 (−4.2, 2.8) | 15.4 | 3.3 |
| Functioning Scales 1 | |||||
| Physical (PF) | 84.1 (81.6, 86.6) | −1.0 (−4.3, 2.3) | −2.0 (−5.2, 1.2) | 15.0 | 4.9 |
| Emotional (EF) | 81.3 (79.3, 83.1) | 4.4 (1.4, 7.5) | 5.0 (2.0, 8.0) | 13.6 | 3.0 |
| Social (SF) | 80.5 (78.1, 83.0) | 0.7 (−3.1, 4.6) | 0.9 (−3.0, 4.7) | 16.3 | 4.6 |
| Role (RF) | 80.4 (77.7, 83.2) | −0.2 (−4.6, 4.2) | −0.5 (−4.9, 3.9) | 18.7 | 5.0 |
| Cognitive (CF) | 84.2 (82.3, 86.2) | 0.5 (−2.5, 3.6) | 0.4 (−2.6, 3.5) | 13.8 | 3.5 |
| Symptom Scales 2 | |||||
| Fatigue (FA) | 30.1 (27.7, 32.6) | −1.8 (−5.7, 2.0) | −1.8 (−5.7, 2.1) | 17.3 | 4.5 |
| Nausea/vomiting (NV) | 4.1 (3.3, 4.9) | 2.8 (1.0, 4.6) | 2.4 (0.6, 4.1) | 7.1 | 0.2 |
| Pain (PA) | 19.0 (16.4, 21.6) | 5.1 (0.9, 9.3) | 4.5 (0.3, 8.6) | 18.3 | 4.9 |
| Dyspnea (DY) | 13.8 (11.7, 15.9) | 0.6 (−3.2, 4.4) | 1.2 (−2.7, 5.0) | 17.4 | 2.9 |
| Sleep (SL) | 30.3 (27.6, 33.0) | −7.3 (−11.9, −2.7) | −7.9 (−12.5, −3.3) | 20.0 | 3.7 |
| Appetite (AP) | 10.7 (8.8, 12.6) | 2.3 (−1.1, 5.7) | 2.2 (−1.2, 5.6) | 13.9 | 2.8 |
| Constipation (CO) | 12.3 (10.6, 14.0) | 6.0 (2.5, 9.5) | 6.3 (2.9, 9.8) | 14.5 | 1.4 |
| Diarrhea (DI) | 10.3 (8.5, 12.1) | −1.4 (−4.4, 1.6) | −1.7 (−4.7, 1.3) | 11.4 | 3.1 |
| Financial insecurity (FI) | 16.4 (13.8, 19.0) | 7.0 (2.7, 11.4) | 5.7 (1.4, 10.0) | 20.2 | 4.2 |
Bolded represents statistical significance at the 0.05 level.
Unadjusted model includes race as the only covariate. Adjusted model additionally includes age and disease state (mHSPC or CRPC) at study enrollment.
All scale scores are rated on a scale of 0-100;
a higher score is indicative of higher quality of life for the global and functioning scales,
while a lower score is indicative of a higher quality of life for the symptom scales.
Interpretation: mean change in EORTC scale score at enrollment for Black participants compared to White participants. For the global and functioning scales, a positive number represents higher quality of life for Black participants compared to White participants. For the symptom scales, a positive number represents lower quality of life for Black participants compared to White participants.