Figure 7. NURF inactivation leads to AML growth arrest and apoptosis.

In AML cells, the NURF complex consists of BPTF, SMARCA5, and BAP18, which remodels chromatin at insulator regions by means of nucleosome sliding, thereby facilitating access of CTCF to its binding sites. This ensures TAD insulation and enhancer‐promoter loop formation, essential to maintain leukemic expression patterns, with MYC transcriptional program representing an important example (left). Upon the KO of the NURF components, the accessibility of the insulator regions is decreased, leading to changes in higher‐order genome organization, altered gene expression and loss of AML cell proliferative capacity (right). Created with BioRender.com.