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. 2023 Dec 6;11(12):e007554. doi: 10.1136/jitc-2023-007554

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Changes in the cytokine and chemokine profile on co-culture of pCRC-SCS or mCRC-SCS with or without NK cells and/or R848. Cytometry bead array performed on the supernatant of pCRC-SCS or mCRC-SCS cultured for 5 days in the presence and absence of NK cells and/or R848. NK cell:SCS ratio 1:1. Cytokine levels: (A) pCRC-SCS and (B) mCRC-SCS. Chemokine levels: (C) pCRC-SCS and (D) mCRC-SCS. pCRC: n=9; 3 NK donors (IL-6 n=5), mCRC: n=6: 3 NK donors. The data are presented as mean±SEM. Significance is presented as p<0.05*, <0.01**, 0.001***, 0.0001****. P values are determined by Friedman ANOVA with Dunn’s multiple comparison analysis or one-way ANOVA with Tukey multiple comparison analysis (pCRC and mCRC: IL-2, CCL4). ANOVA, analysis of variance; CCL, C-C Motif Chemokine Ligand; CRC, colorectal cancer; CXCL, X-C Motif Chemokine Ligand; IFN, interferon; IL, interleukin; mCRC, metastatic CRC, NK, natural killer; pCRC, primary CRC; SCS, single-cell suspensions; T, tumor.