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Summary of adverse events.
| Dose Level 1 (n=4) | Dose Level −1 (n=5) | |||
|---|---|---|---|---|
| AE | All grades | Grade 3–4 | All grades | Grade 3–4 |
| Nausea | 4 | 0 | 4 | 0 |
| Diarrhea | 3 | 2 | 4 | 1 |
| Fatigue | 3 | 0 | 3 | 0 |
| Hypomagnesemia | 3 | 0 | 0 | 0 |
| Thrombocytopenia | 3 | 1 | 0 | 0 |
| Anemia | 3 | 0 | 0 | 0 |
| Anorexia | 3 | 0 | 0 | 0 |
| Abdominal pain | 2 | 0 | 1 | 0 |
| Creatinine increased | 2 | 0 | 1 | 0 |
| Hyponatremia | 2 | 1 | 0 | 0 |
| Neutropenia | 1 | 1 | 1 | 1 |
| Lymphopenia | 1 | 1 | 1 | 1 |
| Hypoalbuminemia | 1 | 1 | 0 | 0 |
| Vomiting | 1 | 0 | 4 | 0 |
| Dermatitis | 0 | 0 | 3 | 0 |
| Alanine aminotransferase | 0 | 0 | 1 | 0 |
