A summary of the main obstacles in protein-based therapy and the corresponding strategies used to overcome these challenges.

Obstacles in protein-based therapy	Strategies to overcome
Protein stability	Formulation optimization, stabilizers, protein engineering for enhanced stability
Immunogenicity	Protein engineering to reduce immunogenic epitopes, immunomodulatory agents
Delivery and targeting	Advanced delivery systems (nanoparticles, liposomes), specific targeting methods
Production costs	Advances in biotechnology, improved manufacturing processes
Dosing precision	Tailoring dosages, controlled-release systems for precision
Regulatory hurdles	Clear documentation, rigorous testing to meet regulatory standards
Short half-life	Modification (e.g., PEGylation) to extend the therapeutic effect, altering formulation
Storage and handling	Proper storage conditions, suitable packaging for preservation