Table 1.

Effects of treatments on kidney, spleen, liver, and body weight of mice at the end of the study

Groups	Kidney (gr)	Spleen (gr)	Liver (gr)	Bodyweight (gr)
N–C	0.156 ± 0.0073	0.1340 ± 0.005	1.164 ± 0.005	27.96 ± 0.1958
P–C	0.158 ± 0.0047	0.5160 ± 0.0269	1.594 ± 0.035	29.72 ± 0.4164
N-MSCs	0.155 ± 0.0041	0.2520 ± 0.012	1.660 ± 0.0594	29.34 ± 0.3586
R-MSCs	0.156 ± 0.0086	0.1680 ± 0.0139	1.464 ± 0.0320	28.96 ± 0.2839
D-MSCs	0.157 ± 0.0015	0.1600 ± 0.0070	1.522 ± 0.0354	28.92 ± 0.3813
DR-MSCs	0.156 ± 0.0097	0.1660 ± 0.0120	1.476 ± 0.0581	29.10 ± 0.2864
Groups	P value for the source of variation
P–C vs N–C	0.3531 (ns)	0.0021 (***)	0.0018 (**)	0.1391 (ns)
P–C vs N-MSCs	0.6954 (ns)	0. 0075 (**)	0.8628 (ns)	0.3063 (ns)
P–C vs R-MSCs	0.4136 (ns)	0.0051 (**)	0.0635 (ns)	0.7007 (ns)
P–C vs D-MSCs	0.6219 (ns)	0.0022 (**)	0.8710 (ns)	0.2021 (ns)
P–C vs DR-MSCs	0.9989 (ns)	0.0010 (**)	0.7541 (ns)	0.8277 (ns)

The statistical significance was determined by One-way analysis of variance (ANOVA). Tukey’s multiple comparisons were used to determine the relationship between the variable’s means. N–C: Negative Control (Healthy mice treated with PBS); P–C: Positive Control (Pristane-immunized mice treated with PBS); N-MSCs (Naïve MSCs without any interventions); R-MSCs: MSCs exposed to lactobacillus rhamnosus; D-MSCs: MSCs exposed to lactobacillus delbrueckii; DR-MSCs: MSCs exposed to a mixture of lactobacillus rhamnosus and delbrueckii. Data were presented as Mean ± Standard Error of the Mean (SEM). P values of ≤ 0.05 were considered significant. (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001)