Fig. 1.

Four transcriptional inhibitory modes of NR1D1. a NR1D1 can bind to a single RORE as a monomer but cannot recruit the co-repressor NCOR1-HDAC3; b NR1D1 can bind to a RORE as a homodimer and recruit the co-repressor NCOR1-HDAC3; c Two NR1D1 monomers can also recruit NCOR1-HDAC3 to repress transcription when they bind independently to two ROREs; d NR1D1 can also coordinate transcriptional repression together with TFs. HDAC3 histone deacetylase 3, NCOR nuclear receptor corepressor, NR1D1 nuclear receptor subfamily 1, group D, member 1, RORE ROR response element, TF transcription factor