Table 6.
Hybridization for EV engineering
| No. | Components for hybridization | Method | Purpose | Ref. |
|---|---|---|---|---|
| 1 | EVs / LNP | Incubation | miRNAs encapsulation | [22] |
| 2 | EVs / LNP | Incubation | miRNAs encapsulation, Targeting, Circulation | [128] |
| 3 | EVs / LNP | PEG incubation | Drug encapsulation, Circulation | [129] |
| 4 | EVs / LNP | Sonication | miRNAs encapsulation | [130] |
| 5 | EVs / LNP | Freeze and thaw | Drug encapsulation, Targeting, Circulation | [131] |
| 6 | EVs / LNP | Freeze and thaw | Drug encapsulation, Circulation | [138] |
| 7 | EVs / LNP | Freeze and thaw | Drug encapsulation, Targeting, Circulation | [139] |
| 8 | EVs / LNP | Freeze and thaw | Drug encapsulation Targeting Circulation | [141] |
| 9 | EVs / LNP | Freeze and thaw | Drug encapsulation Circulation, Targeting | [140] |
| 10 | EVs / NVs | Freeze and thaw | Drug encapsulation, Circulation, Targeting | [19] |
| 11 | EVs / LNP | Extrusion | miRNAs encapsulation, Targeting | [132] |
| 12 | EVs / LNP | Extrusion | Drug encapsulation, Targeting | [146] |
| 13 | EVs / Cell membrane | Extrusion | Targeting | [147] |
| 14 | EVs / LNP | Extrusion | Drug encapsulation, Circulation, Targeting | [142] |
| 15 | EVs / Nanoghost | Extrusion | siRNAs encapsulation, Circulation | [143] |
| 16 | EVs / LNP | Extrusion | siRNAs encapsulation, Circulation | [144] |
| 17 | EVs / LNP | Extrusion after Incubation | Drug encapsulation, Circulation, Targeting | [148] |
| 18 | EVs /Cell membrane | Extrusion after Incubation | Circulation, Targeting | [20] |
| 19 | EVs / LNP | Extrusion after Sonication | miRNAs encapsulation, Targeting, Circulation | [149] |
| 20 | EVs / LNP | Extrusion after Sonication | Drug encapsulation, Targeting, Circulation | [23] |
| 21 | EVs / LNP | Extrusion after Sonication | Drug encapsulation, Targeting, Circulation | [150] |
| 22 | EVs / LNP | Extrusion after Sonication | Drug encapsulation, Circulation, Targeting | [151] |
| 23 | EVs / LNP | Extrusion after Sonication | Drug encapsulation, Circulation, Targeting | [152] |
| 24 | EVs / LNP | Extrusion after Sonication | Drug encapsulation Targeting | [153] |
| 25 | EVs / LNP | Extrusion after Sonication | Drug encapsulation, Circulation, Targeting | [155] |
| 26 | EVs / NV | Extrusion after Sonication | Drug encapsulation, Targeting | [158] |
| 27 | EVs / LNP | EtOH |
Drug encapsulation, Targeting |
[156] |
| 28 | EVs / EVs | Metal-phenolic coordination | Drug encapsulation | [157] |