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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Cell Rep. 2023 Aug 4;42(8):112928. doi: 10.1016/j.celrep.2023.112928

Figure 1. Myeloid-specific expression of the miR-23–27-24 clusters protects against obesity-induced glucose and insulin intolerance.

Figure 1.

(A) Schematic of dietary interventions. Mirc11fl/flMirc22fl/fl (fl/fl) and Mirc11fl/flMirc22fl/flLyz2Cre (MyelΔ) mice were fed a high-fat diet (HFD) for 20 weeks.

(B–E) Body weight curves (B) (two-way ANOVA with Šídák’s multiple comparison test), final body weights and weight gain (C) (two-tailed t test), final body composition measurements by NMR (D) (two-tailed t test), or cumulative energy intake (E) (simple linear regression).

(F) Fasting glucose and insulin levels were recorded following HFD feeding (two-tailed t test).

(G–H) Intraperitoneal glucose (1 g/kg lean mass) (G) or insulin tolerance tests (0.5 U/kg lean mass) (H) were performed on fl/fl and MyelΔ mice after dietary intervention (two-way ANOVA with Šídák’s multiple comparison test for curves; two-tailed t test for area under curve [AUC] comparisons). Male mice 8–10 weeks old at beginning of dietary intervention. Each dot in bar graphs represents one mouse after HFD feeding. B&E, 18–21 mice per genotype. ±SEM. #p = 0.07, *p ≤ 0.05, **p < 0.01, ***p < 0.001. See also Figure S1.