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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Brain Res. 2017 Oct 10;1702:74–84. doi: 10.1016/j.brainres.2017.09.033

Figure 8: Estimated rates of processes in myocardial sympathetic nerves in control subjects and in PD patients.

Figure 8:

Norepinephrine (NE) depletion reflects both denervation (decreased DOPA production) and decreased vesicular storage in the residual sympathetic nerves. The model cannot distinguish decreased vesicular uptake from increased vesicular leakage and decreased intra-vesicular NE synthesis as determinants of tissue NE depletion.