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Schematic diagram of the inhibitory effect of MT RANKL on RANK-RANKL signaling during osteoclastogenesis. GSK-3β, glycogen synthase kinase-3β; LGR4, leucine-rich repeat-containing G-protein-coupled receptor 4; MT, mutant; NFATc1, nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1; RANK, receptor-activated nuclear factor-κB; RANKL, RANK ligand; WT, wild-type.
