Comparison 2. DIACEREIN VS NSAIDs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 WOMAC subscore (Physical Function)	2	345	Mean Difference (IV, Random, 95% CI)	29.50 [‐23.17, 82.17]
1.1 Knee	2	345	Mean Difference (IV, Random, 95% CI)	29.50 [‐23.17, 82.17]
2 Quality of Life	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
3 Adverse Effects	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Diarrhoea	3	505	Risk Ratio (M‐H, Random, 95% CI)	3.20 [1.58, 6.49]
3.2 Dyspepsia	3	505	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.29, 1.61]
3.3 Dizziness	3	505	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.18, 4.15]
3.4 Bowel Motility Disorders	2	321	Risk Ratio (M‐H, Random, 95% CI)	6.95 [2.11, 22.89]
3.5 Rash or Pruritus	1	150	Risk Ratio (M‐H, Random, 95% CI)	5.0 [0.24, 102.42]
4 Drop Out	3	534	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.38, 2.44]
5 Pain VAS 0 to 100	1	150	Mean Difference (IV, Fixed, 95% CI)	2.0 [‐6.48, 10.48]
6 Womac Pain	1	161	Mean Difference (IV, Fixed, 95% CI)	14.0 [‐10.15, 38.15]
7 Pain on walking 20 m	1	213	Mean Difference (IV, Fixed, 95% CI)	1.30 [‐3.81, 6.41]