Nguyen 1994.

Methods	Randomised controlled trial Allocation concealment Double‐blind Placebo‐controlled Parallel‐group Multi‐centre
Participants	Outpatients with hip OA Country: France N = 288; included in this review: 221 Mean age, years: 60 ± 16 Female 57%; male 43%
Interventions	One capsule (50‐mg capsule of diacerein or matching placebo capsules) twice daily and one tablet (20‐mg tablet of tenoxicam or matching placebo tablets) Duration: eight weeks
Outcomes	Pain (100‐mm VAS scale) Functional Lequesne Impairment Index Analgesic consumption Participant overall assessment (0 to 4 scale)
Notes	Supported in part by Negma Pharma Ltd
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Pills were unidentifiable and all participants were allowed to take analgesics
Blinding of outcome assessment (detection bias) Clinical outcomes	High risk	The same investigator did the clinical evaluation and applied questionnaires
Blinding of outcome assessment (detection bias) Radiographic outcomes	Low risk	Not applicable
Incomplete outcome data (attrition bias) All outcomes	Low risk	Withdrawn participants were well described, and all randomly assigned participants were evaluated
Selective reporting (reporting bias)	Low risk	All data were properly reported