Study	Reason for exclusion
Adami 1985	Not a randomised controlled trial
Ascherl 1994	Unpublished study. Diacerein versus placebo for knee OA. Unsuccessful TRB Chemedica contact
Baliga 2010	Inappropriate inclusion criteria
Bogliola 1991	Not a randomised controlled trial The study describes diacerein 50 mg/d every 60 days versus a 30‐day interval compared with falgo balneo therapy for one year
Carrabba 1987	Not a randomised controlled trial. Study analysed use of diacerein 100 mg/d in a group of 31 participants with OA without defined joint for four weeks, in another group of 20 OA participants using diacerein 100 mg/d in a cross‐over arm with naproxen 500 mg/d and in a third group of 20 fibromyalgia participants using diacerein 100 mg/d five days/wk for 12 weeks. The three cohorts were analysed for outcomes on a 0 to 3 scale
Delcambre 1994	Not a randomised controlled trial. Study evaluated 1,221 participants with radiological OA of hip, knee or cervical or lumbar spine using diacerein 100 mg/d for three months as isolated therapy or associated with analgesic or NSAIDs. Outcome measurements inadequate for analysis (VAS 0 to 100 in five grades)
Delcambre 1996	Duplication of the Delcambre 1994 publication
Fagnani 1998	Randomised non blinded study using diacerein and standard therapy for OA including other slow acting anti osteoarthritic drugs plus several procedures that could cause confusion on improvement of end point measurements
Fioravanti 1985	Report of diacerein effectiveness. Symposium presentation not published. Unsuccessfull TRB Chemedica contact
Kay 1980	Not a randomised controlled trial
Leblan 2000	Duplication of the publication of Chantre 2000
Linguetti 1982	Not a randomised controlled trial
Mantia 1987	Clinical study report. Diacerein versus diclofenac for knee and hip OA. Data not available. Unsuccessfull TRB Chemedica contact
Marcolongo 1988	Review on diacerein treatment. No specific data are available for analysis
Mathieu 1999	Case series
Mattara 1985	Data not available. Unsuccessful TRB Chemedica contact
Mazzaro 1989	Not a trial
Mordini 1986	Clinical study. Data not available. Unsuccessful TRB Chemedica contact
Pietrogrande 1985	Data not available. Unsuccessful TRB Chemedica contact
Portioli 1987	Data not available. Unsuccessful TRB Chemedica contact
Renapurkar 2010	Not a randomised controlled trial
Schulitz 1994	Data not available. Unsuccessful TRB Chemedica contact
Seisenbayev 2012	Data not available. Unsuccessful personal contact
Sharma 2008	Not a randomised controlled trial
Singh 2012	Inappropriate inclusion criteria
Tang 2004	Congress abstract later published by Zheng (Zheng 2006) with additional data
Valat 1997	Duplication of the Fagnani study (Fagnani 1998)
Vignon 2002	Comments about ECHODIAH study
Villani 1998	Comment about placebo effects in trials using slow‐acting drugs for OA
Villermay 1994	Comment about the large trial involving 1,221 participants described by Delcambre