Table 2.

Medullary thyroid cancer characteristics as prognostic factors for local recurrence.

Prognostic variable	Hazard ratio (95% CI)	P-value	Multivariate analysis hazard ratio (95% CI)	P-value
N1 disease	10.4 (3.22-33.5)	<.001	5.10 (1.49-17.5)	.01
Vascular invasion	2.20 (1.28-3.79)	.005	1.45 (0.81-2.60)	.21
Extrathyroidal extension	3.23 (1.79-5.83)	.001	1.84 (0.97-3.49)	.06
AJCC stage 3/4	7.08 (3.01-16.55)	<.001	1.21 (0.17-8.59)	.85
Biochemical cure	0.09 (0.03-0.29)	<.001	0.20 (0.06-0.67)	.009
M1 disease (at diagnosis)	0.87 (0.21-3.65)	.85	N/A
Age >55	0.73 (0.40-1.32)	.30	N/A
Germline RET mutation	0.61 (0.30-1.23)	.17	N/A
Pathological high grade	1.52 (0.34-6.91)	.58	N/A

Abbreviation: RET: rearranged during transfection gene.