Table 3.

Predictors of development of distant metastases.

Prognostic variable	Hazard ratio (95% CI)	P-value	Multivariate analysis hazard ratio (95% CI)	P-value
N1 disease	8.82 (2.12-36.6)	.003	10.6 (2.47-45.4)	.001
Vascular invasion	2.55 (1.32-4.92)	.005	1.54 (0.76-3.13)	.23
Extrathyroidal extension	3.51 (1.85-6.66)	<.001	5.04 (2.39-10.6)	<.001
Biochemical cure	0.42 (0.16-1.09)	.074	N/A
High pathological grade	9.1 (2.02-41.0)	.004	3.92 (0.9-17.1)	.010
Local recurrence	0.93 (0.49-1.77)	.83	N/A
Age	1.00 (0.98-1.02)	.87	N/A
Germline RET mutation	0.43 (0.19-0.97)	.04	0.50 (0.22-1.14)	.28

Abbreviation: RET: rearranged during transfection gene.