Table 4.

Predictors of overall survival (OS).

Prognostic variable	Hazard ratio (95% CI)	P-value	Multivariate analysis hazard ratio (95% CI)	P-value
N1 disease	1.89 (0.87-4.12)	.11	N/A
Vascular invasion	2.32 (1.22-4.42)	.01	1.32 (0.46-3.79)	.48
Extrathyroidal extension	2.17 (1.10-4.27)	.025	0.52 (0.10-3.89)	.52
Biochemical cure	0.70 (0.33-1.47)	.35	0.80 (0.33-1.97)	.63
High pathological grade	11.95 (3.56-40.1)	.01	13.15 (2.29-75.5)	.004
Metastatic disease	5.94 (2.86-12.36)	<.001	8.83 (1.39-56.1)	.021
Local recurrence	0.40 (0.20-0.81)	.01	0.73 (0.33-1.61)	.44
Age	1.05 (1.03-1.08)	<.001	1.08 (1.01-1.16)	.018
Germline RET mutation	0.56 (0.23-1.36)	.35	N/A

Abbreviation: RET: rearranged during transfection gene.