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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Sci Transl Med. 2023 Jul 12;15(704):eabq6225. doi: 10.1126/scitranslmed.abq6225

Fig. 6. Macrophage RNF41 induces liver regeneration after hepatectomy.

Fig. 6.

(A) Schematic figure illustrating 70% hepatectomy in healthy mice and administration schedule of dendrimer-graphite nanoparticles linked to pRNF41 (pRNF41-DGNPs) or pSCR (pSCR-DGNPs). (B to E) Liver restoration rate (B), PCNA immunofluorescence staining (C), serum liver injury parameters [ALT, AST, serum albumin, and serum total protein] (D), and HGF and IGF-1 expression (E) in healthy mice undergoing 70% hepatectomy and treated with pSCR-DGNPs or pRNF41-DGNPs. (F) Schematic figure illustrating the time points of fibrosis induction with CCl4, 40% hepatectomy in fibrotic mice, and the administration schedule of pSCR-DGNPs or pRNF41-DGNPs. (G to J) Liver restoration rate (G), PCNA immunofluorescence staining (H), serum liver injury parameters (ALT, AST, serum albumin, and serum total protein) (I), and expression of HGF and IGF-1 in the livers of fibrotic mice undergoing 40% hepatectomy and treated with pSCR-DGNPs or pRNF41-DGNPs. n = 6 animals per group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001 using Student’s t test. Data are shown as means ± SD.