Table 4.
Effect of PGT on the delivery rate and miscarriage rate according to age of women in autologous FET and OD FET (2020).
| Age of women | FET with PGT | FET without PGT | PR (95% CI); p-value | |
|---|---|---|---|---|
| Miscarriagea | Oocyte donors | 11.9% (54/452) | 18.2% (435/2391) | 1.53 (1.17, 1.90); 0.002b |
| Autologous ≤34 |
11.1% (47/424) | 14.9% (394/2640) | 1.35 (1.01, 1.79); 0.041b | |
| Autologous 35-39 |
11.1% (98/879) | 16.6% (516/3112) | 1.49 (1.21, 1.82); <0.001b | |
| Autologous ≥40 |
13.9% (94/675) | 21.9% (317/1449) | 1.57 (1.27, 1.94); <0.001b | |
| Deliverya | Oocyte donors | 39.6% (352/890) | 29.3% (1642/5600) | 0.74 (0.68, 0.82); <0.001c |
| Autologous ≤34 |
40.9% (329/805) | 32.7% (1866/5707) | 0.80 (0.73, 0.88); <0.001c | |
| Autologous 35-39 |
36.4% (679/1866) | 27.6% (2132/7724) | 0.76 (0.71, 0.81); <0.001c | |
| Autologous ≥40 |
35.6% (513/1440) | 19.5% (904/4636) | 0.55 (0.50, 0.60); <0.001c |
FET = frozen embryo transfer; OD FET = oocyte donation frozen embryo transfer;
PGT = preimplantation genetic testing; PR = prevalence ratio.
a
For miscarriage the denominator is clinical pregnancies; for deliveries, the denominator is embryo transfers.
b
Likelihood of having a miscarriage. The reference group is ‘with PGT’.
c
Likelihood of delivery. The reference group is ‘with PGT’.