Table 4.
Clinical characteristics, hormonal profile and reproductive outcomes of normoovulatory infertile women according to rs4886238:G>A variant of the TDRD3 gene.
| Variables | Genotypes TDRD3 rs4886238:G>A | p-value | ||
|---|---|---|---|---|
| GG | GA | AA | ||
| N | 79 | 59 | 11 | - |
| Age (years) | 33.0 (32.0-34.0) | 32.0 (31.0-33.5) | 33.0 (29.7-36.0) | 0.943a |
| BMI (kg/m2) | 23.4 (23.0-24.4) | 24.2 (22.8-25.0) | 25.3 (22.9-27.5) | 0.363a |
| Menarche (years old) | 13.0 (12.0-13.0) | 13.0 (12.0-13.0) | 13.0 (11.4-14.0) | 0.873a |
| Menstrual cycle interval (days) | 28.0 (28.0-29.0) | 28.0 (28.0-29.0) | 29.0 (27.4-30.0) | 0.859a |
| Infertility duration (years) | 3.0 (3.0-4.0) | 3.0 (3.0-4.0) | 3.0 (2.0-6.3) | 0.946a |
| FSH (UI/mL) | 6.1 (5.7-6.8) | 6.0 (5.7-6.4) | 6.2 (4.2-7.3) | 0.888a |
| LH (UI/mL) | 3.0 (2.7-3.4) | 2.9 (2.6-3.3) | 2.8 (2.1-3.4) | 0.826a |
| Progesterone (ng/mL) | 8.1 (3.7-11.0) | 5.8 (2.0-10.8) | 7.3 (1.0-13.2) | 0.868a |
| Prolactin (ng/mL) | 14.8 (12.4-16.9) | 16.9 (14.0-19.4) | 18.9 (9.0-24.9) | 0.377a |
| AMH (ng/mL) | 2.8 (2.0-3.6) | 3.4 (3.0-4.9) | 4.5 (1.7-7.9) | 0.025a |
| AFC | 9 (8.0-10.0) | 9.0 (8.0-10.0) | 9.0 (7.7 -12.4) | 0.858a |
| COS protocol (n, %) 100 UI 150 UI 200 UI |
39 (49.4%) 7 (8.9%) 33 (41.8%) |
28 (47.5%) 9 (15.2%) 22 (37.3%) |
6 (54.5%) 1 (9.1%) 4 (36.3%) |
0.814b |
| Response to COS (n, %) Poor Satisfactory Hyper-response |
16 (20.2%) 51 (64.5%) 12 (15.2%) |
11 (18.6%) 41 (69.5%) 7 (11.8%) |
5 (45.4%) 5 (45.4%) 1 (9.1%) |
0.343b |
| Oocytes retrieved | 5.0 (5.0-7.0) | 6.0 (5.0-9.0) | 4.0 (0.0-6.3) | 0.139a |
| MII Oocytes | 6.0 (4.0-6.7) | 5.0 (4.0-7.5) | 4.0 (0.0-6.0) | 0.201a |
| Embryos | 2.0 (2.0-4.0) | 3.0 (2.0-4.0) | 2.0 (0.0-3.3) | 0.182a |
| Pregnancy rate (n, %) | 24 (30.4%) | 21 (35.6%) | 1 (9.1%) | 0.215b |
The variables were shown as median and CI (95%): 95% Confidence Interval; BMI: body mass index; COH: controlled ovarian hyperstimulation; FSH: follicle stimulating hormone; LH: luteinizing hormone; AMH: anti-Müllerian hormone; AFC: antral follicle counting; MII: oocytes metaphasis II.
a
Mann-Whitney Test and
b
Chi-squared test.