Table 3.

Associations between CPV Status and Late-Mortality.

Cohort	SMN-related mortality			Other-cause mortality			All-cause mortality
	sub HR	95% CI	P-value	Sub HR	95% CI	P-value	HR	95% CI	P-value
SJLIFE	3.40	1.37–8.43	0.0082	1.18	0.50–2.82	0.70	1.89	1.08–3.30	0.025
CCSS	3.58	2.27–5.63	<.0001	1.76	1.11–2.78	0.016	2.45	1.80–3.33	<.0001
Combined *	3.54	2.36–5.32	<.0001	1.61	1.07–2.42	0.021	2.31	1.76–3.02	<.0001

Abbreviations: SJLIFE, St. Jude Lifetime Cohort Study; CCSS, Childhood Cancer Survivor Study; HR, hazard ratio; subHR, subdistribution hazard ratio; SMN, Subsequent Malignant Neoplasm.

^*Combined via fixed-effects meta-analysis based on two study specific models adjusting for genetic ancestry, sex, age at childhood cancer diagnosis, cancer treatment and exposures (chest-RT, alkylating agents, anthracyclines and epipodophyllotoxins). The follow-up started from the first biospecimen collection.