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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Pharmacol Res. 2023 Oct 14;197:106961. doi: 10.1016/j.phrs.2023.106961

Fig. 5.

Fig. 5.

(a) Molecular structures of lofentanil, DAMGO and MP, moieties are colour coded to indicate central and sub-pocket binding. (b) Concentration-response curves of MOR activation by lofentanil, DAMGO and MP, data was generated using TRUPATH BRET and a β-arrestin1/2 BRET assay. (c) Cryo-EM map of MOR bound to MP and in complex with Gαi1βγ (PDB: 7T2G). (d) Cryo-EM map of MOR bound to lofentanil (LFT) in complex with Gαi1βγ stabilized by ScFv16 (PDB: 7T2H). (e) Image showing the side-view of the receptor with MP and LFT occupying the central pocket. (f) Image from the top-view of the receptor showing the overlay of MP and LFT and the occupancy of the two sub-pockets.

Material from Qu et al. [65].