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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Pharmacol Res. 2023 Oct 14;197:106961. doi: 10.1016/j.phrs.2023.106961

Fig. 6.

Fig. 6.

β-arrestin recruitment of (a) MP1104, (b) MP1202 and (c) MP1207/MP1208 measured using a TANGO assay and using human KOR, highlights the decreased β-arrestin recruitment of MP1207/MP1208. (d) Chemical modifications on MP1104 for development of biased analogues. (e) MP1202 ring C favors the boat conformation (green stick) at KOR and resides in a region between TM2-TM3, (f) MP1207 and (g) MP1208 ring C favors a chair conformation (brown stick) at KOR and resides in theTM5-ECL2 region.

Material from Uprety et al. [18].