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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Pharmacol Res. 2023 Oct 14;197:106961. doi: 10.1016/j.phrs.2023.106961

Fig. 7.

Fig. 7.

(a) Diagram detailing the design of bitopic ligands on the fentanyl backbone. (b) Diagram of the bitopic ligand occupying the orthosteric and allosteric pockets in MOR. (c) Cryo-EM structure of MOR bound to bitopic ligand C5 guano, in complex with Gαi1βγ stabilised by ScFv16 (PDB: 7U2L) (d) C5 guano reaches the sodium binding site and (e) interacts with residues in the allosteric sodium binding site. (f) Cryo-EM structure of C6 guano bound to MOR, in complex with Gαi1βγ stabilised by ScFv16 (PDB: 7U2K). (g) C6 guano is able to reach the sodium allosteric site and (h) is close to residues in this site.

Material from: Faouzi et al. [24].