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(a) Chemical modification on fentanyl for development of lead bitopic ligands. (b) β-arrestin1 and β-arrestin2 recruitment to MOR measured for 10 μM agonist, using a BRET assay. (c) TRUPATH BRET concentration-response curves of G protein activation at MOR for fentanyl, C5 guano and C6 guano.
Material from: Faouzi et al. [24].
