FIG 3.

Waterfall plot of best percentage change in the sum of diameters from baseline (n = 225). Snapshot data cutoff, May 18, 2023. Below the waterfall plot, categories of genomic alterations before treatment with HER3-DXd are flagged for each patient (more details on genomic alterations can be found in the Data Supplement, Fig S4) and pretreatment HER3 IHC membrane H-score is shown as a heatmap. Two hundred and ten patients had evaluable target lesion measurements at both baseline and post baseline and are included. ^aT790M was not included as an EGFR-dependent mechanism of EGFR TKI resistance. ^bPretreatment (within 3 months before baseline) tumor HER3 membrane IHC H-score. BICR, blinded independent central review; CR, complete response; EGFR, epidermal growth factor receptor; HER3, human epidermal growth factor receptor 3; IHC, immunohistochemistry; MET, MET proto-oncogene, receptor tyrosine kinase; NE, not evaluable; PD, progressive disease; PR, partial response; SD, stable disease; TKI, tyrosine kinase inhibitor.