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. 2023 Sep 10;41(35):5363–5375. doi: 10.1200/JCO.23.01476

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FIG 4. — Outcomes by CNS BICR in patients with brain metastases at baseline with no previous radiotherapy. (A) Best change from baseline in the sum of diameters of measurable target brain lesions. (B) Intracranial antitumor activity in all patients with brain metastasis at baseline (including nontarget lesions). (C) Contrast-enhanced CT series for the patient with a measurable target lesion who had a confirmed complete intracranial response. ^aCR + PR. ^bEight patients had only nontarget lesions. BICR, blinded independent central review; BOR, best overall response; cORR, confirmed objective response rate; CR, complete response; CT, computed tomography; LD, longest diameter; NE, not estimable/not evaluable; ORR, objective response rate; PD, progressive disease; PR, partial response; SD, stable disease; T, target. Snapshot data cutoff, May 18, 2023.