Table 4.

Points system for classifying DICER1 germline variants. Supporting, moderate, strong, and very strong codes receive 1, 2, 4, and 8 points, respectively, with pathogenic evidence codes in the positive direction, and benign evidence codes in the negative direction. Adapted Tavtigian et al. 2020 (PMID: 32720330)

Category	Point ranges
Pathogenic	≥ 10
Likely Pathogenic	6 to 9
Uncertain	0 to 5
Uncertain with caveat†	−1
Likely Benign	−2 to −6
Benign	≤ −7

^†A final point value of −1 may be overridden to Likely Benign only in cases where PM2_Supporting is applied AND no other pathogenic evidence codes are applied (e.g. BP4, BP7, PM2_Supporting).