Table 2. OS-related factors in BRCA.

Characteristics	Total (N)	HR (95% CI)	P-value	HR (95% CI)	P-value
T stage	1083		0.004
T1	277	Reference		Reference
T2	631	1.336 (0.890–2.006)	0.162	0.928 (0.576–1.494)	0.758
T3	140	1.551 (0.921–2.612)	0.099	1.091 (0.580–2.052)	0.787
T4	35	3.759 (1.959–7.213)	<0.001	1.902 (0.877–4.124)	0.104
N stage	1067		<0.001
N0	516	Reference		Reference
N1	358	1.947 (1.322–2.865)	<0.001	1.591 (1.023–2.476)	0.039
N2	116	2.522 (1.484–4.287)	<0.001	2.888 (1.583–5.269)	<0.001
N3	77	4.191 (2.318–7.580)	<0.001	3.779 (1.714–8.329)	<0.001
M stage	925		<0.001
M0	905	Reference		Reference
M1	20	4.266 (2.474–7.354)	<0.001	1.475 (0.726–2.998)	0.282
PR status	1037		0.191
Negative	342	Reference
Indeterminate	4	0.825 (0.113–6.028)	0.850
Positive	691	0.729 (0.521–1.020)	0.065
ER status	1038		0.005
Negative	240	Reference		Reference
Indeterminate	2	13.090 (3.128–54.779)	<0.001	7.193 (0.892–58.002)	0.064
Positive	796	0.709 (0.493–1.019)	0.063	0.521 (0.290–0.933)	0.028
HER2 status	729		0.095
Negative	560	Reference
Indeterminate	12	0.000 (0.000–Inf)	0.994
Positive	157	1.593 (0.973–2.609)	0.064
PAM50	1086		0.024
Normal	40	Reference		Reference
LumA	563	0.659 (0.302–1.438)	0.295	0.928 (0.326–2.636)	0.888
LumB	206	1.101 (0.486–2.495)	0.818	1.187 (0.404–3.490)	0.755
Her2	82	1.498 (0.621–3.614)	0.369	1.253 (0.385–4.073)	0.708
Basal	195	0.847 (0.371–1.935)	0.694	0.947 (0.303–2.958)	0.925
KLRB1	1086		<0.001
Low	543	Reference		Reference
High	543	0.550 (0.396–0.763)	<0.001	0.533 (0.361–0.787)	0.002

Abbreviations: BRCA: breast invasive carcinoma; OS: overall survival.