Table 3. DSS-related factors in BRCA.

Characteristics	Total (N)	HR (95% CI)	P-value	HR (95% CI)	P-value
T stage	1063		<0.001
T1	275	Reference		Reference
T2	620	1.555 (0.880–2.748)	0.129	1.020 (0.528–1.968)	0.954
T3	134	1.746 (0.838–3.637)	0.137	0.955 (0.379–2.406)	0.922
T4	34	6.713 (3.005–14.992)	<0.001	2.462 (0.932–6.505)	0.069
N stage	1048		<0.001
N0	513	Reference		Reference
N1	348	3.376 (1.918–5.942)	<0.001	2.496 (1.333–4.673)	0.004
N2	112	3.758 (1.758–8.032)	<0.001	4.589 (1.994–10.560)	<0.001
N3	75	7.132 (3.321–15.316)	<0.001	5.613 (1.957–16.095)	0.001
M stage	906		<0.001
M0	887	Reference		Reference
M1	19	7.475 (3.999–13.972)	<0.001	2.102 (0.912–4.846)	0.081
PR status	1018		0.013
Negative	334	Reference		Reference
Indeterminate	4	1.337 (0.180–9.927)	0.777	3.011 (0.357–25.408)	0.311
Positive	680	0.517 (0.333–0.805)	0.003	0.741 (0.302–1.821)	0.514
ER status	1019		0.013
Negative	232	Reference		Reference
Indeterminate	2	7.769 (1.045–57.757)	0.045	0.000 (0.000–Inf)	0.996
Positive	785	0.557 (0.349–0.888)	0.014	0.400 (0.158–1.010)	0.053
HER2 status	718		0.360
Negative	552	Reference
Indeterminate	12	0.000 (0.000–Inf)	0.997
Positive	154	1.477 (0.740–2.948)	0.269
PAM50	1066		0.026
Normal	39	Reference		Reference
LumA	556	1.232 (0.296–5.133)	0.775	1.923 (0.253–14.593)	0.527
LumB	201	2.071 (0.478–8.966)	0.330	1.993 (0.254–15.638)	0.512
Her2	80	3.432 (0.760–15.490)	0.109	1.803 (0.210–15.501)	0.591
Basal	190	2.241 (0.524–9.577)	0.276	1.662 (0.202–13.687)	0.637
KLRB1	1066		0.002
Low	532	Reference		Reference
High	534	0.509 (0.328–0.791)	0.003	0.506 (0.298–0.857)	0.011

Abbreviations: BRCA: breast invasive carcinoma; DSS: disease specific survival.