Table 4. PFI–related factors in BRCA.

Characteristics	Total (N)	HR (95% CI)	P-value	HR (95% CI)	P-value
T stage	1083		<0.001
T1	277	Reference		Reference
T2	631	1.618 (1.045–2.507)	0.031	1.245 (0.756–2.050)	0.389
T3	140	2.184 (1.273–3.747)	0.005	1.360 (0.699–2.647)	0.365
T4	35	6.272 (3.268–12.034)	<0.001	2.274 (0.975–5.303)	0.057
N stage	1067		<0.001
N0	516	Reference		Reference
N1	358	1.973 (1.326–2.936)	<0.001	1.638 (1.047–2.561)	0.031
N2	116	2.485 (1.444–4.279)	0.001	2.748 (1.505–5.018)	<0.001
N3	77	4.959 (2.832–8.684)	<0.001	3.569 (1.606–7.931)	0.002
M stage	925		<0.001
M0	905	Reference		Reference
M1	20	8.345 (4.847–14.368)	<0.001	2.972 (1.370–6.448)	0.006
PR status	1037		0.003
Negative	342	Reference		Reference
Indeterminate	4	0.789 (0.107–5.817)	0.816	0.995 (0.128–7.757)	0.996
Positive	691	0.556 (0.399–0.776)	<0.001	0.579 (0.333–1.008)	0.053
ER status	1038		0.015
Negative	240	Reference		Reference
Indeterminate	2	4.156 (0.570–30.286)	0.160	0.000 (0.000–Inf)	0.994
Positive	796	0.619 (0.434–0.883)	0.008	0.578 (0.324–1.030)	0.063
HER2 status	729		0.759
Negative	560	Reference
Indeterminate	12	1.213 (0.167–8.796)	0.849
Positive	157	1.230 (0.713–2.122)	0.458
PAM50	1086		0.080
Normal	40	Reference
LumA	563	0.722 (0.331–1.574)	0.412
LumB	206	0.871 (0.377–2.015)	0.747
Her2	82	1.536 (0.632–3.738)	0.344
Basal	195	1.081 (0.478–2.445)	0.852
KLRB1	1086		<0.001
Low	543	Reference		Reference
High	543	0.570 (0.410–0.793)	<0.001	0.496 (0.334–0.735)	<0.001

Abbreviations: BRCA: breast invasive carcinoma; PFI: progress free interval.