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. 2023 Dec 11;14(12):815. doi: 10.1038/s41419-023-06352-4

Fig. 2. Mint3 depletion sensitizes TNBC cell lines to chemotherapy in vivo.

Fig. 2

A Schematic illustration of the chemotherapy-induced tumor apoptosis experiments. B–E Immunostaining for cleaved caspase-3 in tumors from control (DOX (−)) and Mint3-depleted (DOX (+)) MDA-MB-231 (B, C) and MDA-MB-468 (D, E) cells 24 h after chemotherapy. B, D Representative images are shown. Bar = 50 µm. C, E Cleaved caspase-3-positive areas were counted in tumor sections. n = 18 from six tumors per group. The data are presented as the mean ± SEM and were analyzed using the Mann–Whitney U-test. *p < 0.05, **p < 0.01, ****p < 0.0001. NS not significant.