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. 2023 Dec 11;14(12):815. doi: 10.1038/s41419-023-06352-4

Fig. 3. A combination of Mint3 depletion and chemotherapy suppresses tumor growth in TNBC cell lines.

Fig. 3

A Schematic illustration of the tumor growth assay. B–E Tumor growth of MDA-MB-231 ishMint3 (B, C) and MDA-MB-468 ishMint3 (D, E) cells in immunodeficient mice treated with or without doxycycline (DOX; 2 mg/mL in tap water) and vehicle, doxorubicin (DXR; 2 mg/kg bw), or paclitaxel (PTX; 20 mg/kg bw). B, D Images of tumors on day 28. Bar = 1 cm. C, E Tumor volume. n = 6 per group. The data are presented as the mean ± SEM and were analyzed using the Mann–Whitney U-test. *p < 0.05. NS not significant.