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. 2023 Dec 11;14:8038. doi: 10.1038/s41467-023-43892-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Panel (a) presents snapshots of all-atom (AA) DOPC bicelles, without and with cholesterol molecules. DOPC within the central bicelle domain are colored in yellow (brown in bicelle rim domain), cholesterol in green, and DTPC molecules in blue. Rendering of the images was done with Blender v3.4.1⁸⁴ and Molecular Nodes v2.4.1⁸⁵. The study analyzes various features of lipid bilayers, including acyl chain order (b), area per lipid (c), and membrane thickness (d), using different setups (CG bicelles as circles and infinite, periodic bilayers as squares) and resolutions (open symbols for CG resolution and filled symbols for all-atom resolution). Error bars were smaller than the symbol size and therefore excluded.