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. 2023 Nov 28;29:1611343. doi: 10.3389/pore.2023.1611343

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Copyright © 2023 Zhang, Jia and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological examination and immunohistochemistry results. (A) The squamous component is composed of keratinized carcinoma nests with polygonal cells containing voluminous cytoplasm (Hematoxylin and eosin, ×400). (B) P40 staining shows nuclear positivity for the squamous carcinoma cells (immunohistochemistry staining, ×200). (C) The prostate adenocarcinoma displays a Gleason score of 5 with a solid pattern (Hematoxylin and eosin, ×100). (D) The expression of prostate-specific marker NXK3.1 confirms the diagnosis (immunohistochemistry staining, ×100). (E) Comparison of genes with high mutation frequencies between squamous cell carcinoma and adenocarcinoma.