Table 3.
Comparison of Detection Rates of Different Pathogen Types Between mNGS and CMT
| mNGS (n, %) | CMT (n, %) | P | |
|---|---|---|---|
| Single bacteria (n = 59) | 56 (94.9) | 33 (55.9) | < 0.001 |
| MTB/NTM a (n = 29) | 29 (100) | 13 (44.8) | < 0.001 |
| MTB a (n = 21) | 21 (100) | 10 (47.6) | < 0.001 |
| Atypical pathogen b (n = 10) | 10 (100) | 3 (30.0) | 0.003 |
| Chlamydia psittaci (n = 8) | 8 (100) | 3 (37.5) | 0.007 |
| Single fungus (n = 24) | 24 (100) | 14 (58.3) | < 0.001 |
| P. jirovecii a (n = 18) | 18 (100) | 4 (22.2) | 0.001 |
| C. neoformans a (n = 7) | 6 (85.7) | 7 (100) | 1.000 |
| Mixed pathogens (n = 20) | 18 (90.0) | 5 (25.0) | < 0.001 |
Notes: aThe number of pathogens includes single infections and mixed infections. bAtypical pathogens include Chlamydia psittaci, Legionella hackeliae, and Chlamydia abortus. Data were presented as n (%). Significance was determined using the Chi-squared test or Fisher’s exact probability method.
Abbreviations: mNGS, metagenomic next-generation sequencing; CMT, comprehensive microbial test; MTB, Mycobacterium tuberculosis complex; NTM, non-tuberculous Mycobacteria; P. jirovecii, Pneumocystis jirovecii; C. neoformans, Cryptococcus neoformans.