Table 2.
The heterogeneity and sensitivity results of RA and thyroid function after removal of pleiotropic IVs.
| Exposure-outcome | nSNP | MR Egger intercept | Cochran’s heterogeneity test | ||||
|---|---|---|---|---|---|---|---|
| Intercept value | P | IVW-Q value | P (IVW) | Egger-Q value | P (Egger) | ||
| Hypothyroidism-RA | 34 | -0.0469 | 0.207 | 1058.7397 | 4.11E-201 | 1006.5788 | 7.05E-191 |
| GD-RA | 4 | 0.1376 | 0.018 | 53.7322 | 1.28E-11 | 1.0231 | 0.600 |
| other types of hyperthyroidism-RA | 6 | 0.1532 | 0.661 | 1057.9187 | 1.73E-226 | 1001.8007 | 1.45E-215 |
| TSH-RA | 39 | -0.0080 | 0.267 | 50.5121 | 0.084 | 48.8353 | 0.092 |
| FT4-RA | 18 | -0.0125 | 0.434 | 35.9153 | 0.005 | 34.5283 | 0.005 |
| RA-Hypothyroidism | 69 | -0.0148 | 0.127 | 505.025 | 5.40E-68 | 469.202 | 1.09E-61 |
| RA-GD | 73 | 0.0276 | 0.067 | 365.270 | 8.23E-41 | 348.305 | 3.41E-38 |
| RA-other types of hyperthyroidism | 78 | 0.0234 | 0.081 | 303.373 | 1.27E-28 | 285.143 | 5.91E-26 |
| RA-TSH | 69 | -0.0034 | 0.143 | 86.6897 | 0.063 | 83.9360 | 0.079 |
| RA-FT4 | 70 | 0.0021 | 0.367 | 78.982 | 0.193 | 78.034 | 0.190 |
MR, Mendelian randomization; IVW, inverse variance-weighted; nSNP, number of single nucleotide polymorphisms; IVW, inverse variance weighted; RA, rheumatoid arthritis; GD, Graves’ disease; FT4, free thyroxine; TSH, thyroid-stimulating hormone.