Table 2.
Brain ROI analysis.
| Tracer | 18F-FPEB | 11C-LSN3172176 | ||
|---|---|---|---|---|
| Brain ROI | NMC bias | UMT bias | NMC bias | UMT bias |
| Amygdala | −7.87% ± 7.80% | 0.44% ± 1.62% | −3.26% ± 6.85% | 0.00% ± 2.60% |
| Caudate | −23.25% ± 14.67% | 1.36% ± 3.49% | −8.62% ± 11.66% | 2.96% ± 2.86% |
| Cerebellum cortex | −0.90% ± 3.19% | 0.85% ± 0.58% | 0.98% ± 3.69% | 0.99% ± 0.56% |
| Frontal | −13.82% ± 5.44% | −0.64% ± 0.86% | −4.65% ± 4.49% | 1.46% ± 0.98% |
| Hippocampus | −6.93% ± 3.70% | −0.83% ± 0.79% | −2.30% ± 6.21% | 0.43% ± 1.99% |
| Insula | −10.24% ± 5.05% | −0.39% ± 1.41% | 0.40% ± 1.11% | 0.83% ± 0.91% |
| Occipital | −3.23% ± 9.96% | 0.48% ± 2.06% | 0.73% ± 2.01% | 3.04% ± 2.45% |
| Parietal | −9.07% ± 4.41% | −1.21% ± 0.63% | 11.90% ± 9.68% | −0.63% ± 1.90% |
| Putamen | −6.59% ± 3.71% | 0.02% ± 1.93% | −1.39% ± 3.97% | 1.22% ± 1.16% |
| Temporal | −10.53% ± 14.82% | 0.09% ± 2.27% | −3.27% ± 2.63% | 1.06% ± 1.37% |
| Thalamus | −9.11% ± 5.11% | −0.27% ± 1.08% | −3.24% ± 2.48% | 1.65% ± 0.78% |
| Cerebellum white matter | 1.34% ± 4.58% | 1.07% ± 0.50% | −1.33% ± 3.69% | 0.12% ± 0.56% |
| Cerebral white matter | 6.78% ± 4.09% | 0.36% ± 0.83% | 1.64% ± 0.64% | −0.68% ± 0.34% |
| Pallidum* | 16.86% ± 4.65% | −0.70% ± 0.96% | 11.90% ± 9.68% | −0.63% ± 1.90% |
|
| ||||
| Grey matter average | −9.23% | −0.01% | −1.16% | 1.18% |
| Grey matter SD | 5.56% | 0.73% | 4.90% | 1.06% |
| White matter average | 4.06% | 0.72% | 0.16% | −0.28% |
| White matter SD | 2.72% | 0.35% | 1.48% | 0.40% |
No motion correction (NMC) and UIH motion tracking (UMT) bias values shown as average ± standard deviation of the % difference with respect to Vicra values across all subjects. Paired sample t-test shows that NMC absolute bias is significantly greater than UMT (p < 0.05) in 12/14 ROIs (p < 0.1 in the remaining 2 ROIs). SD: standard deviation.