Fig. 7.

Crosstalk between Yap with Hh signaling factors. Upon Hippo pathway inactivation, activated YAP/TAZ translocate into the nucleus and interact with the TEAD family transcription factors, thereby by promoting the expression of target genes of YAP, including Ankrd1, Ctgf, Areg, etc. VP inhibits YAP through direct binding with its cofactor TAZ, thereby inhibiting the interactions with its downstream cofactors, TEAD. Inhibition of Yap exhibited suppression effect on TAA-induced Shh, Smo, Gli1 and Gli2. YAP yes-associated protein, TAZ transcriptional coactivator with PDZ-binding motif, VP verteporfin, Smo smoothened, SHH sonic hedgehog, PTCH1 patched 1, Gli GLI family zinc finger, Ctgf connective tissue growth factor, Areg amphiregulin; connective tissue growth factor, Ankrd1 ankyrin repeat domain 1