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. 2023 Jul 26;8(10):1298–1314. doi: 10.1016/j.jacbts.2023.05.012

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Effects of Sema Treatment or PF on Differentially Expressed VAT Genes and Pathways

(A) Venn diagram of differently expressed visceral adipose tissue (VAT) genes for Sema treatment (n = 6) or PF (n = 6) and their direction vs Veh treatment (n = 6). (B, C) Curated GO Biological Processes list of genes identified in the VAT demonstrating unique up-regulated (B) and down-regulated (C) pathways enriched by Sema treatment compared to Veh treatment. Circle size reflects gene ratio, which is proportion of differentially expressed genes in a pathway divided by all differentially expressed genes that map to the GO term. Color-coding reflects P value after Gprofiler Threshold (P < 0.05). Abbreviations as in Figures 1 and 4.