Figure 4.

Next-Generation 5-HT_2B Ligands for Human Translation

VU6055320 is a robust substrate for P-glycoprotein−mediated efflux and is predicted to be highly restricted to the periphery in human subjects. ^aRadioligand binding assays for 5-HT_2B, 5-HT_2A, and 5-HT_2C subtypes by Eurofins Panlabs Discovery Services (Taiwan) according to standard protocols. NC = not calculated; all % inhibition <50. ^bP-gp efflux rate

(P-gp ER) data provided by Absorption Systems. Classification of brain penetration potential: high = P-gp ER <3.0; moderate = 10 > P-gp ER >3.0; low = P-gp ER >10.