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Schematic pathway diagram showing the three stages of peptidoglycan biosynthesis (cytoplasmic precursor synthesis, membrane translocation, and polymerization and cross-linking) impacted by ceftazidime/avibactam treatment (48/4 mg/L) at 6 h. The diagram also shows the bar charts and table for the significantly impacted metabolites and genes involved in this metabolic pathway, respectively (log2FC ≥ 0.59 or ≤ −0.59, p < 0.05, false discovery rate (FDR) < 0.05).
